AB0836 DIAGNOSIS VALUE OF INTERLEUKIN 17 IN SPONDYLOARTHRITIS

Background: Interleukin 17 (IL-17) is pro-inflammatory cytokine that plays a crucial role in spondyloarthritis via the Th17/IL-17 axis. (1) Objectives: We aimed to study diagnosis value of IL-17 serum spondyloarthritis. Methods: conducted case-control study, including 104 subjects divided into 2 groups: -G1: 52 patients meeting Assessment SpondyloArthritis International Society (ASAS) criteria for (SA) -G2: healthy controls matched age and sex. The level was measured using Enzyme-linked immunosorbent assay (ELISA). performed ROC analysis computed air under curve (AUC) at assess ability diagnose SA. Statistical “IBM SPSS Statistics” software version 25. Results: Eighty per cent were men (n=41). mean 44.96 ± 13.09 years. onset disease 35.07 12.66 duration 9.25 8.09 Axial radiographic peripheral involvement found 53.8% (n=28) 44.2% (n=23) cases, respectively. Psoriasis noted 46% cases (n=24). ASDAS-CRP 3.21 1.64. significantly higher compared (92.76 71.85 pg/mL 2.67 9.01 pg/mL, respectively, p<0.0001). As shown Figure 1, AUC distinguish between control 0.987 (p<0.0001). cut-off 13.79 (Sensibility= 94.2%, specificity=98.1%). 1. SA (p<0.0001) Conclusion: According previous studies, our showed (2). Interestingly, able with pg/mL. This finding suggests may be useful References: [1]Ruiz de Morales JMG, Puig L, Daudén E, Cañete JD, Pablos JL, Martín AO, et al. Critical interleukin (IL)-17 inflammatory immune disorders: An updated review evidence focusing controversies. Autoimmun Rev. janv 2020;19(1):102429. [2]Chen W-S, Chang Y-S, Lin K-C, Lai C-C, Wang S-H, Hsiao K-H, Association interleukin-17 interleukin-23 levels activity Chinese ankylosing spondylitis. J Chin Med Assoc. juill 2012;75(7):303-8. Disclosure Interests: None declared